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. Author manuscript; available in PMC: 2023 Apr 21.
Published in final edited form as: Mol Cell. 2022 Apr 21;82(8):1477–1491. doi: 10.1016/j.molcel.2022.03.025

Figure 4. XBPIs and/or ATF6 activation promote distinct remodeling of ERQC pathways.

Figure 4.

XBPIs and ATF6 induce expression of specific, but overlapping, sets of ERQC factors that differentially impact ER function. ERQC genes primarily up-regulated by XBP1s are shown in green, while those primarily induced by ATF6 are depicted in purple. Genes targeted by both XBP1s and ATF6 to similar extents are shown in red, whereas genes regulated cooperatively by ATF6 and XBP1s activation are in blue. Image was adapted from (Shoulders et al., 2013) where the individual expression of ERQC factors induced by XBP1s and/or ATF6 activation in the absence of ER stress was measured in HEK293 cells. Created with BioRender.com.