Scheme 20. Recent application of baker's yeast in the total synthesis of alkaloids: (a) reductive kinetic resolution of β-ketoester rac-160 in the synthesis of isodaphlongamine H (167), (b) synthesis of paspaline (173) featuring reductive desymmetrisation of β-diketone 168 by baker's yeast and local desymmetrisation of 171 by Pd2+-catalysed diastereoselective C–H acetoxylation.
