Scheme 46. Applications of strictosidine synthase in medicinal chemistry: (a) chemo-enzymatic synthesis of N-substituted 3,14,18,19-tetrahydroangustines (363) as topoisomerase 1 inhibitors, (b) condensation of secologanin (357) with non-natural amine substrate 364 to give azepinoindole derivative (4S)-366, and its conversion into the antimalarial 367.
