Kinetic resolution of primary alcohols using immobilised CAL-B.

Substrate	Conditions	Products	ee [%]	E a	Ref.
	Toluene, 12 mM 178, 2 eq. vinyl acetate	(R)-178	99	>200	96a
		(S)-acetate	99
	Flow (80 bar, 0.1 mL min−1), 60 °C
	Toluene, 12 mM 179, 4 eq. vinyl acetate	(R)-179	30	88	96b
	Batch, Et3N, Na2SO4, 3 °C	(S)-acetate	97
	Toluene, 12 mM 180, 2 eq. vinyl acetate	(R)-180	rac	1	96a
	Flow (80 bar, 0.1 mL min−1), 60 °C	(S)-acetate	rac
	Toluene, 12.5 mM 181, 2 eq. Ac2O	(R)-181	98	>200	97
	Batch, 60 °C	(S)-acetate	98
	Toluene, 12.5 mM 182, 8 eq. Ac2O	(R)-182	98	>200	97
	Batch, 60 °C	(S)-acetate	98
	Toluene, 12.5 mM 183, 6 eq. Ac2O	(R)-183	96	>200	97
	Batch, 60 °C	(S)-acetate	98

^aEnantioselectivity, calculated from ee of substrate and product.