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. 2021 Aug 25;11(46):28711–28715. doi: 10.1039/d1ra04814g

Substrate scope for the reactiona.

graphic file with name d1ra04814g-u2.jpg
graphic file with name d1ra04814g-u3.jpg n = 1, 1, 93%b (91%)c
n = 2, 2, 88%b (85%)c
n = 3, 3, 89%b (87%)c
n = 4, 4, 85%b (84%)c
n = 5, 5, 90%b (91%)c
n = 6, 6, 92%b (90%)c
graphic file with name d1ra04814g-u4.jpg n = 1, 7, 96%b (93%)c
n = 3, 8, 92%b (87%)c
n = 4, 9, 95%b (91%)c
n = 5, 10, 90%b (86%)c
n = 6, 11, 92%b (87%)c
graphic file with name d1ra04814g-u5.jpg n = 1, 12, 96%b (93%)c
n = 4, 13, 98%b (96%)c
n = 5, 14, 97%b (94%)c
n = 6, 15, 96%b (92%)c
graphic file with name d1ra04814g-u6.jpg n = 1, 16, 95%b (93%)c
n = 3, 17, 91%b (87%)c
n = 4, 18, 88%b (85%)c
n = 5, 19, 85%b (81%)c
graphic file with name d1ra04814g-u7.jpg n = 1, 20, 91%b (88%)c
n = 2, 21, 93%b (90%)c
n = 4, 22, 94%b (91%)c
graphic file with name d1ra04814g-u8.jpg n = 1, 23, 92%b (87%)c
n = 2, 24, 89%b (85%)c
n = 3, 25, 87%b (81%)c
n = 4, 26, 90%b (84%)c
graphic file with name d1ra04814g-u9.jpg n = 1, 27, 87%b (81%)c
n = 2, 28, 84%b (77%)c
n = 4, 29, 81%b (74%)c
n = 6, 30, 78%b (76%)c
graphic file with name d1ra04814g-u10.jpg n = 1, 31, 93%b (89%)c
n = 3, 32, 95%b (90%)c
n = 5, 33, 96%b (88%)c
graphic file with name d1ra04814g-u11.jpg n = 1, 34, 68%b (72%)c
n = 2, 35, 62%b (74%)c
n = 4, 36, 60%b (70%)c
a

Conditions: potassium carboxylate (10 mmol), dihaloalkane (5 mmol), TBAB (1 mmol), 120 °C for 3 h.

b

Average isolated yield from two reactions of the dibromoalkanes.

c

Average isolated yield from two reactions of the dichloroalkanes.

d

105 °C for 3 h.

e

110 °C for 3 h.