Table 1.
Demographic, clinical, and relapse characteristics for all 23 evaluable patients with relapses
| Case number | Sex | Age | Stage | Site of bulk | Response (RER, SER) | Site of SER | No. of sites of relapse | Site(s) of relapse | No. of relapse sites involved at dx | No. of relapse sites initially bulky | No. of relapse sites PET2 negative | No. of relapse sites out-of-field | No. of out-of-field relapse sites would theoretically have been covered by IFRT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||||
| 1 | M | 18 | IIIB | LMA | RER | 5 | L hilar, R paratracheal, pericardium, subcarinal, celiac | 4 out of 5 | 3 out of 4 | 4 out of 4 | 2 out of 5 | 1 out of 2 | |
| 2 | F | 21 | IVB | LMA; spleen | RER | 11 | L cervical, epicardial, L hilar, R hilar, mediastinum, R paratracheal, subcarinal, celiac, L paraortic, R paraortic, spleen | 10 out of 11 | 3 out of 10 | 10 out of 10 | 5 out of 11 | 5 out of 5 | |
| 3 | F | 14 | IVB | L neck | RER | 1 | L supraclavicular | 1 out of 1 | 1 out of 1 | 1 out of 1 | 0 out of 1 | n/a | |
| 4 | F | 14 | IVB | LMA | RER | 2 | Celiac, L paraortic | 1 out of 2 | 0 out of 1 | 1 out of 1 | 2 out of 2 | 2 out of 2 | |
| 5 | M | 17 | IVB | LMA; L axilla | RER | 11 | R cervical, R hilar, R infraclavicular, R paratracheal, subcarinal, celiac, L paraortic, portal, spleen, R axillary, R iliac | 5 out of 11 | 0 out of 5 | 5 out of 5 | 8 out of 11 | 4 out of 8 | |
| 6 | M | 16 | IIIB | L axilla | RER | 3 | R supraclavicular, R paratracheal, retrotracheal | 2 out of 3 | 0 out of 3 | 3 out of 3 | 3 out of 3 | 3 out of 3 | |
| 7 | M | 17 | LMA; spleen | RER | 3 | Mediastinum, L paraortic, R paraortic | 3 out of 3 | 1 out of 3 | 3 out of 3 | 2 out of 3 | 2 out of 2 | ||
| 8 | F | 16 | IIIB | Spleen | RER | 6 | R hilar, mediastinum, subcarinal, L paraortic nodes, portal, R pectoral | 4 out of 6 | 0 out of 4 | 4 out of 4 | 6 out of 6 | 5 out of 6 | |
| 9 | M | 16 | IVB | LMA | RER | 3 | L paraortic, R paraortic, portal | 1 out of 3 | 0 out of 1 | 1 out of 1 | 3 out of 3 | 3 out of 3 | |
| 10 | M | 15 | IVB | LMA | RER | 3 | L hilar, L lung, subcarinal | 1 out of 3 | 0 out of 1 | 1 out of 1 | 1 out of 3 | 0 out of 1 | |
| 11 | M | 14 | IVB | none | RER | 2 | R Iliac, skin/subcutaneous | 1 out of 2 | 0 out of 1 | 1 out of 1 | 2 out of 2 | 0 out of 2 | |
| 12 | M | 8 | IVB | LMA; spleen | SER | R supraclav; mediastinum | 5 | Supraclavicular (L), supraclavicular (R), mediastinum, paratracheal (R), paratracheal (L) | 5 out of 5 | 1 out of 5 | 4 out of 5 | 0 out of 5 | n/a |
| 13 | F | 15 | IVB | LMA; L supraclav | SER | L supraclav; mediastinum | 5 | Cervical (R), supraclavicular (L), supraclavicular (R), mediastinum, subcarinal | 5 out of 5 | 2 out of 5 | 3 out of 5 | 1 out of 5 | 1 out of 1 |
| 14 | F | 16 | IVB | LMA; spleen | SER | Spleen | 4 | Cervical (L), supraclavicular (L), axillary (L), pectoral (L) | 3 out of 4 | 0 out of 3 | 3 out of 3 | 3 out of 4 | 1 out of 3 |
| 15 | M | 16 | IVB | L paraortic; spleen | SER | Spleen, bone | 8 | R cervical, R paratracheal, pericardium, subcarinal, periaortic/esophageal, R axillary, L inguinal, L pectoral | 3 out of 8 | 0 out of 3 | 3 out of 3 | 8 out of 8 | 5 out of 8 |
| 16 | F | 13 | IVB | LMA | SER | Mediastinum | 3 | R cervical, epicardial, mediastinum | 3 out of 3 | 1 out of 3 | 2 out of 3 | 2 out of 3 | 2 out of 2 |
| 17 | M | 17 | IIIB | LMA; spleen | SER | Mediastinum; spleen | 2 | R supraclavicular, liver | 1 out of 2 | 0 out of 1 | 1 out of 1 | 2 out of 2 | 1 out of 2 |
| 18 | M | 15 | IVB | LMA | SER | L supraclav/axilla; mediastinum | 9 | Epicardial, subcarinal, celiac, R paraortic, portal, L retrocrural, R retrocrural, spleen, R iliac | 4 out of 9 | 0 out of 4 | 4 out of 4 | 7 out of 9 | 6 out of 7 |
| 19 | F | 15 | IIIB | Celiac; portal; spleen | SER | Spleen | 2 | Liver, mesenteric | 1 out of 2 | 0 out of 1 | 1 out of 1 | 2 out of 2 | 1 out of 2 |
| 20 | F | 17 | IVB | Spleen | SER | Spleen | 3 | L supraclavicular, L iliac, L inguinal | 3 out of 3 | 0 out of 3 | 3 out of 3 | 3 out of 3 | 3 out of 3 |
| 21 | M | 15 | IIIB | Spleen | SER | Bilat neck | 4 | L lung, R lung, R paratracheal, subcarinal | 2 out of 4 | 0 out of 2 | 2 out of 2 | 1 out of 4 | 0 out of 1 |
| 22 | M | 14 | IIIB | LMA; spleen | SER | Mediastinum | 5 | L lung, celiac, liver, L paraortic, portal | 0 out of 5 | n/a | n/a | 4 out of 5 | 0 out of 4 |
| 23 | M | 10 | IIIB | LMA; spleen | SER | Spleen | 5 | Celiac, L paraortic, R paraortic, portal, L axillary | 3 out of 5 | 0 out of 3 | 3 out of 3 | 4 out of 5 | 3 out of 4 |
Abbreviations: IFRT = involved-field radiation therapy; L = left; LMA = large mediastinal adenopathy; PET2 = second cycle of chemotherapy; R = right; RER = rapid early response; SER = slow early response.