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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Nature. 2021 Sep 21;599(7885):465–470. doi: 10.1038/s41586-021-04017-w

Fig. 4: Prophylactic activity of anti-SARS-CoV-2 mAbs is enhanced by selective engagement of activating FcγRs.

Fig. 4:

In a model of mAb-mediated prophylaxis of SARS-CoV-2 infection (a), the activity of wild-type and GAALIE variants of the REGN mAb cocktail was assessed. FcγR humanized mice were treated (i.v.) at the indicated dose with REGN mAb cocktail expressed as wild-type human IgG1 or as GAALIE variant one day prior to challenge with SARS-CoV-2 (MA10, 104 pfu i.n.). Weight loss (mean ± s.e.m.) (c, left panel) and survival curves (b and c, right panel) of antibody-treated mice were compared with the PBS-treated group by two-way ANOVA (Bonferroni post hoc analysis adjusted for multiple comparisons) and log-rank (Mantel–Cox) test, respectively. P values are indicated. NS, not significant. b, n= total of 7 mice per group (n=6 mice/group for 2 mg/kg) from two independent experiments; c, n= total of 7 (WT) or 9 (PBS, GAALIE) mice per group from three independent experiments.