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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Nature. 2021 Sep 21;599(7885):465–470. doi: 10.1038/s41586-021-04017-w

Extended Data Fig. 5: In vitro neutralization activity and antigenic specificity of Fc variants of anti-SARS-CoV-2 mAbs.

Extended Data Fig. 5:

To confirm that changes in the Fc domain have no effect on the neutralization activity and Fab-mediated functions of anti-SARS-CoV-2 mAb, Fc domain variants were characterized in (a-c) in vitro neutralization assays using SARS-CoV-2MA10 pseudotyped reporter viruses and (d, e) in ELISA assays using SARS-CoV-2 RBD. n= 1 experiment performed in duplicates. (a, d) REGN and (b, e) BMS/RU mAb cocktails were expressed as Fc variants and their in vitro neutralization activity (a, b, c, IC50 values) and (d, e) antigenic specificity was compared among Fc variants.