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. 2022 Apr 25;11:e70810. doi: 10.7554/eLife.70810

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© 2022, Greenspan et al

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Figure 5. — (A) In wild type testes, EGF ligands (red circles) are secreted by germ cells and received by cyst lineage cells. The EGFR pathway is repressed in hub cells by the secreted inhibitor Argos (yellow squares), which sequesters EGF ligands, and by intrinsic pathway inhibitors (Sprouty and PTEN). Hub quiescence and identity are maintained. (B) After genetic ablation of all CySCs and early cyst lineage cells, EGF ligands are no longer sequestered by Argos and are received by the hub. The EGFR pathway is activated in hub cells, driving expression of the downstream transcription factor Pointed and its target genes, resulting in hub cell proliferation and conversion to CySCs. As new CySCs are generated, Argos is once again expressed, down-regulating EGFR signaling in the hub.