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. 2022 Apr 11;10:832431. doi: 10.3389/fchem.2022.832431

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Copyright © 2022 Ewert, Günther, Miglioli, Falke, Reinke, Niebling, Günther, Han, Srinivasan, Brognaro, Lieske, Lorenzen, Garcia-Alai, Betzel, Carcelli, Hinrichs, Rogolino and Meents.

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Effects of the identified binders on substrate cleavage rates. (A) Ubiquitin-cleavage rate of PLpro in the presence of 500 µM or 5 µM compound. (B) ISG15-cleavage rate of PLpro in the presence of 500 µM or 5 µM compound. Compounds coloured according to Figure 3; protein shown in grey. Average of four independent experiments with standard deviation shown.