TABLE 3.
Static and dynamic parameters of the bone biopsies
| Histomorphometric bone parameters | Baseline (N = 68) | 12 mo (N = 69) | P |
|---|---|---|---|
| Cortical bone | |||
| Porosity (%) | 7.4 (4.9–10.6) | 5.9 (3.8–9.8) | 0.094 |
| Thickness (μm) | 737.9 (552.7– 973.9) | 629.2 (403.5–849.2) | 0.006 |
| Porosity >10%, n (%) | 23 (33.3) | 18 (26.1) | 0.297 |
| Trabecular bone | |||
| Bone volume/tissue volume (%) | 18.8 (14.3–24.3) | 19.3 (15.8–24.8) | 0.339 |
| Osteoid surface/bone volume (%) | 3.2 (1.7–4.9) | 4.2 (2–5.8) | 0.660 |
| Osteoid thickness (μm) | 7.8 (6.7–10.3) | 9.1 (6.8–12.6) | 0.005 |
| Osteoid volume/bone volume (%) | 3.2 (1.7–4.9) | 4.2 (2.0–5.8) | 0.261 |
| Mineralized bone volume/tissue volume (%) | 18.3 (13.7–23.0) | 18.4 (14.7–23.6) | 0.389 |
| Osteoblast surface/bone surface (%) | 2.3 (0.7–5.5) | 1.9 (1.1–3.2) | 0.030 |
| Osteoclast surface/bone surface (%) | 1.3 (0.2–2.5) | 0.4 (0–0.9) | <0.001 |
| Adjusted mineral apposition rate (μm/d) | – | 0.3 (0.1–0.4) | – |
| Bone formation rate (μm3/μm2/d) | – | 21.4 (4.7–32.2) | – |
| Mineralization lag time (d) | – | 40.3 (25.5–85.0) | – |
| Low bone volume, n (%) | 22 (32.3) | 18 (26.5) | 0.513 |
| Normal bone turnover, n (%) | 33 (48.5) | 31(44.9) | 0.590 |
| Low-turnover bone disease, n (%) | 15 (22.1) | 31 (44.9) | 0.001 |
| Adynamic bone disease | 7 (10.3) | 10 (14.5) | 0.405 |
| Osteomalacia | 1 (1.5) | 3 (4.3) | 0.157 |
| High-turnover bone disease, n (%) | 20 (29.4) | 7 (10.1) | <0.001 |
| Mixed renal osteodystrophy | 2 (2.9) | 0 (0) | 0.157 |
Statistical analysis was performed using the Wilcoxon matched-pair signed-rank test or the McNemar test. Bold values when P < 0.05.