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. 2022 Apr 18;2022:9304383. doi: 10.1155/2022/9304383

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Copyright © 2022 Wei Yu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Schematic illustration of HUA promoting atherosclerosis by triggering ferroptosis in macrophage-derived foam cells. HUA induces mitochondrial dysfunction and inhibits NRF2 signaling, which may in turn impair macrophage autophagy and increase foam cell ferroptosis, thereby accelerating atherosclerosis. GPX4: glutathione peroxidase; GSH: glutathione; HFD: high fat diet; HUA: high level of uric acid; NRF2: nuclear factor erythroid 2-related factor 2; OAT: organic anion transporter; oxLDL: oxidized low-density lipoprotein; ROS: reactive oxygen species; UA: uric acid.