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. 2022 Apr 22;6(5):e0713. doi: 10.1097/HS9.0000000000000713

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Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Hematology Association.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 7. — Cox model of inflammatory cytokine load in 70 patients with CCUS, LR-MDS, and HR-MDS. Adjusted for age, sex, case status, and comorbidities. Inflammatory cytokine load: low: 0–3 of 4 cytokines increased compared with upper 95% limit of healthy elderly controls. High: 4 of 4 cytokines increased compared with upper 95% limit of healthy elderly controls; case status: CCUS; LR-MDS; HR-MDS; co-morbidities included diabetes mellitus, ischemic heart disease, and autoinflammatory diseases. Events: numbers of death patients during follow-up. *P < 0.05. Log-rank tests were used to determine if individual cytokines (categorized as normal/abnormal) were independently associated with OS. Cox proportional hazard model was used for multivariable analysis. AIC = Akaike’s Information Criterion; CCUS = clonal cytopenias of undetermined significance; HR-MDS = higher-risk myelodysplastic syndromes; LR-MDS = lower-risk myelodysplastic syndromes; OS = overall survival.