Table 1.
Correlation between lncRNAs and angiogenesis in tumors
| Classification | LncRNA | Cancer | Expression | Mechanism | Biological functions | Ref |
|---|---|---|---|---|---|---|
| CeRNA | LINC00173.v1 | lung squamous cell carcinoma | up | ΔNp63α/LINC00173.v1/miR-511-5p/VEGFA axis | promoting tumorigenesis and angiogenesis | 60 |
| MYLK-AS1 | hepatocellular carcinoma | up | miR-424-5p/E2F7/VEGFR-2 axis | promoting proliferation, invasion, migration, and angiogenesis | 61 | |
| MALAT1 | up | miR-140/VEGFA axis | promoting angiogenesis and changing polarization of macrophage | 62 | ||
| SNHG17 | colorectal carcinoma | up | miR-23a-3p/CXCL12 axis | promoting viability proliferation, migration, and angiogenesis | 63 | |
| SNHG22 | gastric carcinoma | up | miR-361-3p/HMGA1/Wnt/β-catenin axis | promoting proliferation, angiogenesis, and transition from G1 phase to S phase; inhibition of apoptosis | 64 | |
| TUG1 | osteosarcoma | up | miR-143-5p/HIF-1α | promoting invasion and angiogenesis | 65 | |
| Signaling pathway | SRRM2-AS | nasopharyngeal carcinoma | up | MYLK/cGMP/PKG axis | promoting proliferation, colony formation, angiogenesis; regulating cell cycle; inhibition apoptosis | 66 |
| LINC01314 | gastric carcinoma | down | KLK4/Wnt/β-catenin axis | inhibiting migration, invasion, and angiogenesis | 67 | |
| Angiogenic factors and receptors | EPIC1 | non-small cell lung cancer | up | Ang2/Tie2 axis | promoting angiogenesis | 68 |
| Recruitment of RNA polymerase | RAB11B-AS1 | breast cancer | up | HIF-2/Rab11B-AS1/RNA Pol II/VEGFA and ANGPTL4 | promoting migration, invasion, angiogenesis, and distant metastasis | 69 |
| Exosome | TUG1 | cervical cancer | up | exosome transfer | promoting angiogenesis | 70 |
| Gene transcription | LINC00261 | prostate cancer | down | DKK3/GATA6/VEGF and CD31 | inhibiting proliferation, migration, invasion, tumorigenicity, and angiogenesis | 71 |
| SLC26A4-AS1 | glioma | down | NFKB1/NPTX1 | Inhibiting cell viability, proliferation, migration, invasion and angiogenesis | 72 | |
| LINC00320 | down | NFKB1/AQP9 | inhibit proliferation and angiogenesis | 73 | ||
| Tumor associated macrophage | MALAT1 | thyroid cancer | up | TAMs FGF2 protein | promoting proliferation, migration, invasion, angiogenesis | 74 |
| Cancer stem cells | H19 | hepatocellular carcinoma | up | exosome transfer | promoting tube formation and cell-cell adhesion | 75 |