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. 2022 Dec 31;15(3):515–524. doi: 10.1038/s41385-021-00482-8

Fig. 2.

Fig. 2

S-protein-induced type I IFN and chemokine responses are exaggerated in post COVID-19 MDM.a PCA of RNAseq datasets (baseline, S-protein, LPS) for seronegative (n = 4–8) or post CoV (n = 8–16) MDM. b Volcano plot of DEGs for post CoV MDM (n = 8) ± S-protein. DEGs with log2 FC > 5 or padj < 0.00001 (DESeq2) are labeled, DEGs with log2 FC > 1 and padj < 0.1 are colored. c Heatmap of top 50 DEGs in post CoV MDM (n = 8–16) ± S-protein, padj < 0.1, log2 FC > 1, base mean > 50. d Volcano plot of DEGs of S-protein-stimulated MDM from seronegative (n = 4) vs. post-CoV (n = 8) donors. DEGs with log2 FC > 2.5 or padj < 0.003 are labeled, DEGs with log2 FC > 1 and padj < 0.1 are colored. e Heatmap of top 50 DEGs of MDM ± S-protein from seronegative (n = 4) or seropositive (n = 8) donors, padj<0.1, log2 FC > 1, base mean > 50.