Table 2.

Overall Survival and Progression-Free Survival by Clinical Characteristics for Patients with Vulvar Squamous Cell Carcinoma.

Variable	Overall survival VSCC†			Progression-free survival VSCC†
	95% CI	HR	p-valuea	95% CI	HR	p-valuea
Recurrence: Y vs. N	1.529 – 30.36	6.814	0.0118*	N/A	N/A	N/A
Age: ≥60 vs. <60 (REF)	0.2702 – 5.298	1.196	0.8132	0.3528 – 2.887	1.009	0.9863
Stage: III vs. I	0.5904 – 22.74	3.664	0.1633	0.3452 – 3.867	1.156	0.8146
Margin (mm):<8 vs. ≥8 (REF)	0.2319 – 10.93	1.592	0.6360	0.3972 – 5.929	1.535	0.5345
Post-op chemo: N vs. Y	0.4373 – 24.92	3.301	0.2468	0.5579 – 8.255	2.146	0.2666
Post-op radiation: N vs. Y	0.4864 – 23.79	3.401	0.2173	0.6723 – 8.534	2.395	0.1778
Smoking: Y vs. N	0.2439 – 4.872	1.090	0.9100	0.2470 – 2.016	0.7056	0.5151
Focality: Multifocal vs. unifocal	0.2612 – 10.32	1.641	0.5972	1.312 – 28.38	6.103	0.0211*
LVSI: N vs. Y	0.3429 – 10.13	1.863	0.4711	0.4019 – 4.393	1.329	0.6413
LN: pos vs. neg	1.610 –160.5	16.07	0.0180*	0.3149 – 5.818	1.353	0.6842
Surgery: Wide local excision vs. vulvectomy	0.03909 – 1820	8.435	0.0151*	0.02283 – 4669	10.33	0.0064*
Nodal dissection: N vs. Y	0.5591 – 142.6	8.927	0.0003*	0.6909 –61.38	6.512	0.0001*
Re-excision: N vs. Y	0.1830 – 9.165	1.295	0.7956	0.04323 –1.553	0.2591	0.1394
Depth (mm): ≥8 vs. <8 (REF)	0.2414 – 4.792	1.076	0.9238	0.1453 – 1.306	0.4357	0.1381
Tumor size (mm):≤30 vs. >30 (REF)	0.2553 – 5.486	1.184	0.8294	0.5302 – 4.358	1.520	0.4358
History of Lichen sclerosus: N vs. Y	0.1743 – 4.965	0.9303	0.9326	0.3492 – 3.418	1.092	0.8793

Abbreviations: VSCC, vulvar squamous cell carcinoma; HR, hazard ratio; CI, confidence interval; Y, yes; N, no; N/A, not applicable; mm, millimeters; post-op, post-operative; chemo, chemotherapy; LVSI, lymphovascular space invasion; LN, lymph nodes.

^†Calculations were performed using the log-rank test in GraphPad Prism® version 9.0.0.

^aP-values are reported for tests of statistical significance. All comparisons were two-tailed and the alpha error was set at 5%.

^*Statistically significant.