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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: J Heart Lung Transplant. 2021 Nov 25;41(5):641–653. doi: 10.1016/j.healun.2021.11.012

Figure 2. Proliferation to donor-specific and pooled HLA at 2 years post-transplant.

Figure 2.

PBMC from IPF and non-IPF lung transplant recipients 2 years post-transplant were stimulated with donor-derived matched sBc or pooled sBc from multiple donors in a mixed lymphocyte reaction. Proliferation of (A) CD8+ T cells and (B) CD4+ conventional T cells. Differences between IPF and non-IPF groups were assessed using unpaired Student’s t-test. Changes in (C) CD8+ T cells and (D) CD4+ Tconv are shown over time for the two groups in response to stimulation with matched donor-derived sBc. The dashed line highlights a subject who developed CLAD at the 2-year time point. The percentage of proliferating cells pre- and post-transplant were compared by two-tailed paired Student’s t-test.