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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: J Heart Lung Transplant. 2021 Nov 25;41(5):641–653. doi: 10.1016/j.healun.2021.11.012

Figure 6. Short peripheral blood telomere length is associated with impaired alloimmune responses.

Figure 6.

Telomere length was measured in PBMC DNA using quantitative PCR and shown for IPF, non-IPF, and non-transplant referents (healthy) both pre-transplant and at 2 years post-transplant (A). Telomere length was shorter in IPF subjects compared with non-IPF and non-transplant referents as assessed by unadjusted GEE models (P < 0.001). For Non-IPF versus healthy, we observed P = 0.09. (B) Telomere length measurements are shown stratified by cytokine profile cluster, as identified in Figure 4. After multiple comparison adjustments clusters 3 and 4, with impaired cytokine production, were found to have shorter telomere lengths than the clusters 1 and 2. Percent proliferation to matched or single donor alloantigens is shown versus telomere length for CD8+ T cells (C) and CD4+ Tconv (D). P-values represent statistical significance for the association of proliferation with telomere length as assessed by unadjusted GEE models.