Table 4.
Patient distribution according to ISS/R-ISS scores and unsupervised clustering results.
| GEM05 under 65 | Cluster 1 | Cluster 2 | Cluster 1 vs Cluster 2 p value |
|---|---|---|---|
| ISS 1 | 9.09% | 29.18% | <1 × 10−4 |
| ISS 2 | 15.74% | 25.57% | 0.02 |
| ISS 3 | 11.80% | 8.52% | 0.21 |
| RISS 1 | 0.98% | 27.54% | 0.49 |
| RISS 2 | 26.88% | 35.74% | 6.10 × 10−3 |
| RISS 3 | 8.85% | 0% | NA |
| GEM05 over 65 | Cluster 1 | Cluster 2 | Cluster 1 vs Cluster 2 OS p value |
|---|---|---|---|
| ISS 1 | 9.18% | 28.18% | 0.32 |
| ISS 2 | 15.74% | 25.57% | 0.06 |
| ISS 3 | 11.80% | 8.52% | 0.02 |
| RISS 1 | 0.98% | 27.54% | NA |
| RISS 2 | 26.89% | 35.74% | 8.20 × 10−3 |
| RISS 3 | 8.85% | 0%% | NA |
| GEM2012 under 65 | Cluster 1 | Cluster 2 | Cluster 1 vs Cluster 2 OS p value |
|---|---|---|---|
| ISS 1 | 15.72% | 27.51% | 0.57 |
| ISS 2 | 11.79% | 18.78% | 4.50 × 10−3 |
| ISS 3 | 16.59% | 9.61% | 0.08 |
| RISS 1 | 1.31% | 26.63% | 0.52 |
| RISS 2 | 32.75% | 28.82% | 0.01 |
| RISS 3 | 10.04% | 0.44% | 0.55 |
Statistical significance (cox p values) for differential OS between both clusters in each subgroup is shown.