Table 4.
Comparison of sex-specific cumulative incidence of CHD vs. Stroke from age 45 years across the three epochs, adjusted for competing risk of death
| Mortality-adjusted Cumulative Incidence (95% CI), 1960–1979 | Mortality-adjusted Cumulative Incidence (95% CI), 1980–1999 | Mortality-adjusted Cumulative Incidence (95% CI), 2000–2018 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 30-year | 40-year | Lifetime | 30-year | 40-year | Lifetime | 30-year | 40-year | Lifetime | ||
| Hard CHD | ||||||||||
| Women | N/PYrs | 170/48511 | 234/53666 | 243/54040 | 119/46597 | 249/58842 | 327/63404 | 76/53519 | 131/63861 | 198/68921 |
| ACI | 9.1 (7.8–10.4) |
17.1 (14.8–19.4) |
21.0
(17.3–24.8) |
6.8 (5.6–7.9) |
13.4 (11.8–14.9) |
18.3
(16.5–20.2) |
4.0 (3.1–4.9) |
7.9 (6.6–9.2) |
12.8
(11.1–14.5) |
|
| Men | N/PYrs | 401/35854 | 466/38551 | 470/38667 | 318/38249 | 485/44516 | 532/45963 | 145/42208 | 205/49292 | 234/51694 |
| ACI | 26.0 (23.7–28.2) |
34.5 (31.7–37.4) |
36.0
(32.9–39.1) |
20.5 (18.5–22.6) |
31.5 (29.2–33.8) |
35.5
(33.1–38.0) |
9.1 (7.7–10.5) |
14.0 (12.2–15.8) |
17.1
(15.0–19.1) |
|
| P, Men vs. Women | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | 0.002 | |
| Stroke | ||||||||||
| Women | N/PYrs | 98/48358 | 152/53300 | 154/53664 | 66/46885 | 181/59119 | 255/63499 | 34/53918 | 82/64459 | 158/69654 |
| ACI | 5.5 (4.4–6.6) |
11.8 (9.8–13.8) |
13.4
(10.2–16.6) |
3.8 (2.9–4.7) |
9.7 (8.4–11.1) |
14.5
(12.8–16.1) |
1.8 (1.2–2.5) |
5.2 (4.1–6.3) |
10.7
(9.1–12.3) |
|
| Men | N/PYrs | 115/37384 | 149/40156 | 155/40267 | 93/40463 | 163/47309 | 178/48843 | 58/43793 | 93/51605 | 112/54316 |
| ACI | 7.7 (6.3–9.1) |
12.8 (10.6–14.9) |
15.7
(12.6–18.7) |
5.9 (4.7–7.0) |
10.5 (8.9–12.0) |
11.9
(10.3–13.6) |
3.6 (2.7–4.5) |
6.3 (5.1–7.6) |
8.2
(6.7–9.7) |
|
| P, Men vs. Women | 0.014 | 0.51 | 0.33 | 0.005 | 0.48 | 0.035 | 0.002 | 0.18 | 0.025 | |
| Total ASCVD | ||||||||||
| Women | N/PYrs | 588/44158 | 745/47889 | 758/48144 | 381/42715 | 696/51957 | 858/54889 | 255/50714 | 421/59009 | 595/62413 |
| ACI | 31.4 (29.2–33.5) |
49.3 (46.3–52.3) |
54.7
(50.7–58.8) |
22.8 (20.8–24.8) |
40.2 (37.9–42.5) |
51.4
(49.0–53.9) |
13.9 (12.3–15.5) |
27.0 (24.7–29.3) |
42.4
(39.7–45.1) |
|
| Men | N/PYrs | 797/31864 | 903/33715 | 911/33783 | 579/34051 | 798/38269 | 852/39148 | 315/39056 | 451/44407 | 531/45860 |
| ACI | 51.3 (48.7–53.9) |
64.5 (61.5–67.5) |
67.8
(64.4–71.2) |
39.5 (37.0–42.1) |
55.8 (53.1–58.4) |
61.2
(58.5–63.8) |
21.0 (18.9–23.1) |
34.1 (31.5–36.8) |
45.6
(42.5–48.7) |
|
| P, Men vs. Women | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | 0.13 | |
ACI= adjusted cumulative incidence %. N = number of ASCVD events, Pyrs= person-years of observation.