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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: Kidney Int. 2022 Feb 26;101(5):963–986. doi: 10.1016/j.kint.2022.01.030

Figure 3. Myeloid cell-specific conditional deletion of Mfn2 but not Mfn1 aggravates kidney fibrosis.

Figure 3.

Figure 3.

Figure 3.

a - c) Representative western blots and densitometry analysis in kidney tissue lysates for the expression of fibronectin (FN), TGF-β1, alpha-smooth muscle actin (α-SMA), CD206, arginase-I (Arg-I), and galectin-3 (Gal-3) from mice fed with control (Ctl) or adenine diet (AD) for 28 days in a) Mfn1fl/fl,LysM-Cre-−/− and Mfn1fl/fl,LysM-Cre+/− mice; b) Mfn2fl/fl,LysM-Cre-−/− and Mfn2fl/fl,LysM-Cre+/− mice, and c) Wild-type and Mfn1/Mfn2 double knockout (DKO) mice, normalized to GAPDH, n = 6 per group. Data are mean ± SEM representative of 3 independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001, analyzed by one-way ANOVA followed by Newman-Keuls post-hoc test.