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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: Kidney Int. 2022 Feb 26;101(5):963–986. doi: 10.1016/j.kint.2022.01.030

Figure 9. Mfn2-deficient monocytes/macrophages displayed increased production of mitochondrial-specific oxidative stress.

Figure 9.

Flow cytometry analysis and representative histograms showing the mean fluorescence intensity (MFI) of mitochondrial-derived superoxide detected using MitoSox dye in the a - b) F4/80+ CD45+ cells in the kidneys from control (Ctl) or adenine (AD) diet (28-days)-fed wild-type, Mfn1fl/fl,LysM-Cre+/−, and Mfn2fl/fl,LysM-Cre+/− mice (a) and wild-type and Mfn1/Mfn2 double knockout (DKO) mice (b). c) CD11b+ circulating monocytes in the AD fed wild-type, Mfn1fl/fl,LysM-Cre+/−, and Mfn2fl/fl,LysM-Cre+/− mice Data are mean ± SEM representative of 3 independent experiments, (n = 5 per group). *P < 0.05, **P < 0.01, and ***P < 0.001, analyzed by one-way ANOVA followed by Newman-Keuls post-hoc test.