Table 1.
Demographic and clinical characteristics of study subjects.
| NL | CD | EoC | P value | |
|---|---|---|---|---|
| Subjects (n) | 20 | 14 | 27 | |
| Demographic features | ||||
| Age at biopsy (min.–max. years) | 15.1 (4.3–44.9) | 17.3 (11.7–21.6) | 14.0 (7.1–64.4) | .26 |
| Gender (% Male) | 8 (40%) | 7 (50%) | 14 (52%) | .71 |
| Race (% White) | 18 (90%) | 14 (100%) | 25 (93%) | .49 |
| Colonic eosinophil counts | ||||
| Peak (eos/HPF) | 28.5 (23.8–37.5) | 48.5 (31.0–68.3) | 55.5 (23.8–100.8) | .025 |
| Range (min.–max. eos/HPF) | 2–43 | 16–110 | 9–187 | |
| Biopsies (n) | ||||
| Total | 29 | 27 | 31 | - |
| Active or inflamed | - | 16 | 12 | - |
| Normal | 16 | - | - | - |
| Right colon | 10 | 14 | 21 | - |
| Left colon | 19 | 13 | 10 | - |
| History of EGIDs | ||||
| EoE | - | - | 15 (56%) | - |
| EoG | - | - | 5 (19%) | - |
| EoC | - | - | 27(100%) | - |
| History of atopy | ||||
| Atopy (any) | 15 (75%) | 8 (57%) | 15 (56%) | .36 |
| Asthma | 7 (35%) | 2 (14%) | 6 (22%) | .36 |
| Allergic rhinitis | 13 (65%) | 5 (36%) | 11 (41%) | .16 |
| Eczema | 8 (40%) | 3 (21%) | 9 (33%) | .52 |
| Food allergy | 5 (25%) | 0 (0%) | 7 (26%) | .11 |
| Treatment at biopsy | ||||
| Ongoing diet therapy | 9 (45%) | 2 (14%) | 12 (44%) | .12 |
| Proton pump inhibitor | 11 (55%) | 0 (0%) | 9 (33%) | .004 |
| Topical steroids | 3 (15%) | 0 (0%) | 8 (30%) | .059 |
| Systemic steroids | 0 (0%) | 4 (29%) | 2 (7%) | .019 |
| Immune modulator | 0 (0%) | 2 (14%) | 0 (0%) | < .001 |
| Biologies | 0 (0%) | 9 (64%) | 0 (0%) | < .001 |
*
Data are n (%) or median (interquartile range [IQR]) unless otherwise stated.
CD, Crohn disease; EoC, eosinophilic colitis; EGIDs, eosinophilic gastrointestinal diseases; EoE, eosinophilic esophagitis; EoG, eosinophilic gastritis; eos/HPF, eosinophils per high-power microscopic field; max., maximum; min., minimum; NL, normal.