Table 2:
Associations between brainstem volumes and Alzheimer’s disease pathology
| Predictor | Neocortical PiB | Entorhinal FTP | Inferior Temporal FTP | Fusiform FTP | Amygdala FTP |
|
| |||||
| N=267 | N=238 | N=238 | N=238 | N=238 | |
| Medulla | −0.12±0.06 (0.036) | 0.03±0.06 (0.677) | −0.04±0.06 (0.522) | −0.04±0.06 (0.545) | 0.03±0.06 (0.611) |
| Pons | −0.11±0.06 (0.047) | 0.01±0.07 (0.844) | −0.04±0.06 (0.482) | −0.02±0.07 (0.740) | −0.08±0.06 (0.213) |
| Midbrain | −0.13±0.06 (0.022) | −0.02±0.06 (0.783) | −0.11±0.06 (0.065) | −0.10±0.06 (0.123) | −0.12±0.06 (0.057) |
| Striatum | 0.02±0.06 (0.668) | −0.05±0.07 (0.463) | −0.01±0.06 (0.849) | −0.08±0.07 (0.227) | 0.01±0.07 (0.843) |
| Hippocampus * | 0.07±0.10 (0.520) | 0.13±0.12 (0.250) | −0.15±0.10 (0.140) | 0.05±0.11 (0.630) | −0.07±0.11 (0.56) |
| Fourth Ventricle ┼ | 0.02±0.06 (0.802) | −0.10±0.07 (0.137) | −0.08±0.06 (0.202) | −0.06±0.07 (0.412) | −0.01±0.07 (0.832) |
|
Interactions with neocortical PiB | |||||
| Medulla x Neocortical PiB | 0.530 | 0.480 | 0.870 | 0.98 | |
| Pons x Neocortical PiB | 0.460 | 0.690 | 0.360 | 0.62 | |
| Midbrain x Neocortical PiB | 0.170 | 0.490 | 0.960 | 0.68 | |
|
Non-PVC analyses | |||||
| Predictor | Neocortical PiB | Entorhinal FTP | Inferior Temporal FTP | Fusiform FTP | Amygdala FTP |
|
| |||||
| N=267 | N=238 | N=238 | N=238 | N=238 | |
| Medulla | −0.13±0.06 (0.024) | −0.01±0.06 (0.835) | −0.03±0.06 (0.645) | −0.04±0.06 (0.548) | −0.02±0.06 (0.755) |
| Pons | −0.13±0.06 (0.023) | −0.06±0.07 (0.335) | −0.09±0.06 (0.157) | −0.07±0.07 (0.300) | −0.12±0.06 (0.070) |
| Midbrain | −0.10±0.06 (0.094) | −0.06±0.06 (0.354) | −0.12±0.06 (0.054) | −0.14±0.06 (0.026) | −0.16±0.06 (0.011) |
| Striatum | 0.02±0.06 (0.726) | −0.10±0.07 (0.143) | −0.04±0.07 (0.522) | −0.11±0.07 (0.110) | −0.05±0.07 (0.422) |
| Hippocampus * | 0.05±0.10(0.600) | 0.23±0.12 (0.050) | −0.02±0.11 (0.850) | 0.06±0.11 (0.580) | 0.00±0.11 (0.97) |
|
Interactions with neocortical PiB | |||||
| Medulla x Neocortical PiB | 0.230 | 0.480 | 0.280 | 0.41 | |
| Pons x Neocortical PiB | 0.370 | 0.600 | 0.180 | 0.72 | |
| Midbrain x Neocortical PiB | 0.100 | 0.530 | 0.190 | 0.70 | |
Note: β±SE (p-value) presented unless otherwise specified. For interaction analyses only the p-value is presented. All models adjusted for age, sex, and camera. Analyses were also adjusted for total cranial volume. Neocortical PiB was log transformed for normality. Top section of the table shows the partial volume corrected (PVC)-results, the bottom part the non-PVC results.
: Number of observations for hippocampal volume was n=257 for associations with neocortical PiB and n=227 for tau measures.
: Number of observations for fourth ventricle was n=231 for associations with neocortical PiB and n=219 for tau measures.
Abbreviations: PVC = partial volume correction; PiB= Pittsburgh Compound; FTP = Flortaucipir