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. 2022 Apr 25;6:28. doi: 10.1038/s41698-022-00270-y

Fig. 2. cfRNA profiles distinguish between non-cancer, MGUS, and multiple myeloma donors.

Fig. 2

a Boxplots of representative top ten most significant genes resulted from the LVQ analysis for MM versus NC. P value was calculated for each pair by the t-test. Center-line indicates the median value across all patients in that group, and the hinges represent the lower (Q1) and upper (Q3) quartile, with whiskers extending to the minimum and maximum of the resulting distribution. b Heatmap of z-score across publicly available tissue-level expression data from the Human Protein Atlas (HPA) for the top ten LVQ genes identified in MM vs. NC. c LDA plot using ten genes from pairwise analysis across NC - MGUS and NC - MM pairs using the LVQ method. d–f LOOCV using the Random Forest (RF) model with top ten LVQ genes to discriminate MGUS and NC (d), MM vs MGUS (e), and three groups NC, MGUS, and MM (f). Genes included in the RF analysis are listed in Supplementary Table 5.