Table 2.

Overview of OTA and 2′R-OTA serum levels of blood donors in Switzerland — results from 2019 (phase I n = 700, phase II n = 240), 2005 (n = 355) and 1995 (n = 366)

	% ≥ LOQ	Meana [ng/mL]			Median [ng/mL]			Maximum [ng/mL]
		All	Female	Male	All	Female	Male
OTA
2019 Phase Ib	98.7	0.42	0.33	0.50	0.27	0.26	0.30	23.0
2019 Phase IIc	99.2	0.38	0.36	0.40	0.28	0.27	0.31	1.73
2005	99.2	0.40	0.32	0.47	0.28	0.28	0.28	14.6
1995d	100	0.39	0.27	0.49	n.d.	0.24	0.30	6.02
2′R-OTA
2019 Phase I	48.1	0.23	0.24	0.22	n.d.	n.d.	n.d.	1.31
2019 Phase II	52.1	0.24	0.24	0.23	0.10	0.11	0.10	1.15
2005	50.7	0.20	0.20	0.20	0.10	0.10	0.10	0.98

^aMean is calculated in positive samples, excluding values < LOD

^b1 extreme value of approx. 700 ng/mL was excluded

^cPhase II samples: 240 samples taken 2–9 months later from Phase I donors

^ddata from Zimmerli and Dick (1995)

n.d. not determined