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. 2022 Apr 25;13:2236. doi: 10.1038/s41467-022-29912-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a NMF cluster analysis of ATAC-seq data from 50 patient-derived GSC cultures. b Distribution of TCGA subtypes among ATAC50 clusters. c Distribution of MCO subgroups among ATAC50 clusters. d Heatmap of unique ATAC peaks of each ATAC50 cluster. Examples of genes annotated to the chromatin regions are indicated. e Genomic annotation of all ATAC peaks in the hGSC cohort and unique ATAC peaks of each ATAC50 cluster. f NMF cluster analysis of DRE ATAC peaks from 50 human GSC cultures. g Overlap of ATAC50 clusters with DRE-guided clusters. Source data are provided as a Source Data file for Fig. 3a–g.