Fig. 7.

Effect of mice pre-treatment with glibenclamide (20 mg/kg, i.p.) on the antinociceptive effect of a supercritical CO₂ extract of Aloysia gratissima leaves (EAG) (10 mg/kg, p.o.) on the formalin test. Nociceptive behavior in the first phase (A, 0–5 min) or second phase (B, 15–30 min) of the test. Ketorolac (20 mg/kg, i.p.) was used as positive control. Each column represents the mean ± S.E.M. (n = 4–7 mice/group). Two-Way ANOVA followed by the Student-Newman-Keuls test, ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001 compared to vehicle plus vehicle-treated group. ###p < 0.001 compared to the vehicle plus kerotolac-treated group; §§§p < 0.01 compared to vehicle plus EAG-treated group.