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. 2022 Apr 12;13:876550. doi: 10.3389/fphar.2022.876550

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Copyright © 2022 Jiang, Zhang, Zheng, Sun and Ding.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Que reduced lipid peroxidation and ferroptosis in the livers of HFD-fed mice. (A,B) The levels of 4-HNE and GSH/GSSG in the liver (n = 6). (C) Iron content in the liver (n = 6). (D) Representative Western blot images. (E–G) Quantitative analysis of ferroptosis-related proteins (GPX4, COX-2 and ACSL4) in the liver (n = 3). The data are expressed as the mean ± SD. **, p < 0.01 and *, p < 0.05.