TABLE 2.

Metabolic pathway analysis based on MetPA.

Pathway name	Class	Total	Expected	Hits	Raw p	−LOG10(p)	Holm adjust	FDR	Impact	Hits/Total	Potential biomarkers
Linoleic acid metabolism	Lipid metabolism	5	0.0530	2	0.0010	2.9850	0.0870	0.0870	1.0000	0.4000	PC(22:0/P-18:0), Linoleic acid
Arachidonic acid metabolism	Lipid metabolism	36	0.3817	2	0.0539	1.2688	1.0000	0.8310	0.3329	0.0556	PC(22:0/P-18:0), Arachidonic acid
Glyoxylate and dicarboxylate metabolism	Carbohydrate metabolism	32	0.3393	1	0.2916	0.5353	1.0000	1.0000	0.2196	0.0313	Hydroxypyruvic acid
Arginine and proline metabolism	Amino acid metabolism	38	0.4029	2	0.0594	1.2265	1.0000	0.8310	0.1685	0.0526	L-Arginine, Ornithine
Arginine biosynthesis	Amino acid metabolism	14	0.1484	2	0.0089	2.0502	0.7395	0.3742	0.1371	0.1429	L-Arginine, Ornithine
Steroid hormone biosynthesis	Lipid metabolism	77	0.8164	1	0.5693	0.2447	1.0000	1.0000	0.1275	0.0130	L-Palmitoylcarnitine
Glycerophospholipid metabolism	Lipid metabolism	36	0.3817	2	0.0539	1.2688	1.0000	0.8310	0.1118	0.0556	PC(22:0/P-18:0), LysoPC(20:5(5Z,8Z,11Z,14Z,17Z))
Glycine, serine and threonine metabolism	Amino acid metabolism	34	0.3605	1	0.3068	0.5131	1.0000	1.0000	0.0425	0.0294	Hydroxypyruvic acid
Sphingolipid metabolism	Lipid metabolism	21	0.2227	1	0.2018	0.6951	1.0000	1.0000	0.0243	0.0476	Sphingosine 1-phosphate
Glycolysis/Gluconeogenesis	Carbohydrate metabolism	26	0.2757	1	0.2438	0.6129	1.0000	1.0000	0.0002	0.0385	D-Glucose
Biosynthesis of unsaturated fatty acids	Lipid metabolism	36	0.3817	2	0.0539	1.2688	1.0000	0.8310	0.0000	0.0556	Linoleic acid, Arachidonic acid
Ascorbate and aldarate metabolism	Carbohydrate metabolism	10	0.1060	1	0.1014	0.9940	1.0000	1.0000	0.0000	0.1000	Glucaric acid
Phenylalanine metabolism	Amino acid metabolism	12	0.1272	1	0.1205	0.9191	1.0000	1.0000	0.0000	0.0833	Hippuric acid
alpha-Linolenic acid metabolism	Lipid metabolism	13	0.1378	1	0.1299	0.8864	1.0000	1.0000	0.0000	0.0769	PC(22:0/P-18:0)
Glutathione metabolism	Metabolism of other amino acids	28	0.2969	1	0.2601	0.5849	1.0000	1.0000	0.0000	0.0357	Ornithine
Fatty acid degradation	Lipid metabolism	39	0.4135	1	0.3437	0.4639	1.0000	1.0000	0.0000	0.0256	L-Palmitoylcarnitine
Aminoacyl-tRNA biosynthesis	Genetic Information Processing, Translation	48	0.5090	1	0.4054	0.3921	1.0000	1.0000	0.0000	0.0208	L-Arginine