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. 2022 Apr 12;10:831332. doi: 10.3389/fbioe.2022.831332

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Copyright © 2022 Niu, Han, Dong, Yang, Li, Zhang, Hu, Xia, Li and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Combination of PCR-CRISPR detection with ERASE strip for lateral flow readout. (A) Schematic of PCR-CRISPR detection with lateral flow strip. (B,C) Sensitivity of PCR-CRISPR detection with lateral flow strip. (B) Detection of wild-type target RNA by PCR-CRISPR and wild-type crRNA followed by application to the lateral flow strip. (C) Detection of mutant target RNA by PCR-CRISPR and mutant crRNA followed by application to the lateral flow strip. (D,E) Specificity of PCR-CRISPR detection with the lateral flow strip. (D) PCR-CRISPR with lateral flow strip can discriminate other viral RNA. (E) PCR-CRISPR with lateral flow strip achieves specific detection of other viral mutant or deletion sites.