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. 2022 Apr 25;8:227. doi: 10.1038/s41420-022-00949-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A The expression of JMJD2C in uveal melanoma tissues as determined by RT-qPCR (uveal melanoma = 32, normal = 30). B The expression of JMJD2C in normal uveal epithelial cells ARPE-19, uveal melanoma cells MUM-2B, and drug-resistant cell line MUM-2B/CDDP as determined by RT-qPCR. C The protein expression of JMJD2C after sh-JMJD2C or oe-JMJD2C treatment in the MUM-2B/CDDP cells and MUM-2B cells, respectively, as measured by Western blot assay. D The cell viability and IC50 in MUM-2B/CDDP cells after JMJD2C silencing and MUM-2B cells after JMJD2C overexpression as assessed by CCK-8 assay. E The senescence rate of MUM-2B/CDDP cells after JMJD2C silencing and MUM-2B cells after JMJD2C overexpression as assessed by SA-β-gal staining. F The migration and invasion abilities of MUM-2B/CDDP cells after JMJD2C silencing and MUM-2B cells after JMJD2C overexpression as assessed by Transwell assay. * p < 0.05. Cell experiments were repeated three times independently.