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. 2022 Apr 25;8:227. doi: 10.1038/s41420-022-00949-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A The expression of MDM2 in uveal melanoma tissues as determined by RT-qPCR (uveal melanoma = 32, normal = 30). B The expression of MDM2 in normal uveal epithelial cells ARPE-19, uveal melanoma cells MUM-2B, and drug-resistant cell line MUM-2B/CDDP as determined by RT-qPCR. C The expression of MDM2 in MUM-2B/CDDP cells after JMJD2C silencing and MUM-2B cells after JMJD2C overexpression as measured by Western blot assay. D Enrichment degree of H3K9me3 in MDM2 promoter region in MUM-2B/CDDP cells after JMJD2C silencing and MUM-2B cells after JMJD2C overexpression as determined by ChIP. E The expression of MDM2 silenced by shRNAs in MUM-2B/CDDP cells as measured by Western blot assay. F The protein expression of JMJD2C and MDM2 in MUM-2B/CDDP cells treated with sh-MDM2 or combined with oe-JMJD2C as measured by Western blot assay. G The viability and IC50 of MUM-2B/CDDP cells treated with sh-MDM2 or combined with oe-JMJD2C as assessed by CCK-8 assay. H The senescence rate of MUM-2B/CDDP cells treated with sh-MDM2 or combined with oe-JMJD2C as assessed by SA-β-gal staining. I The migration and invasion abilities of MUM-2B/CDDP cells treated with sh-MDM2 or combined with oe-JMJD2C as assessed by Transwell assay. * p < 0.05. Cell experiments were repeated three times independently.