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. 2022 Apr 25;8:227. doi: 10.1038/s41420-022-00949-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A The expression of p53 in normal uveal epithelial cells ARPE-19, uveal melanoma cells MUM-2B, and drug-resistant cell line MUM-2B/CDDP as determined by RT-qPCR. B The expression of p53 in MUM-2B/CDDP cells upon JMJD2C silencing and MUM-2B cells upon JMJD2C overexpression as measured by Western blot assay. C The expression of p53 in MUM-2B cells upon MDM2 overexpression as measured by Western blot assay. D The stability of p53 protein after CHX treatment. E The expression of IL5RA in uveal melanoma tissues as determined by RT-qPCR (uveal melanoma = 32, normal = 30). F The expression of IL5RA in normal uveal epithelial cells ARPE-19, uveal melanoma cells MUM-2B and drug-resistant cell line MUM-2B/CDDP as determined by RT-qPCR. G IL5RA expression in MUM-2B/CDDP cells upon p53 overexpression and MUM-2B cells upon p53 silencing measured by Western blot assay. H The enrichment of p53 in the IL5RA promoter region in MUM-2B/CDDP cells and MUM-2B cells analyzed by ChIP. I The expression of MDM2, p53, and IL5RA in MUM-2B cells treated with oe-MDM2 or combined with oe-p53 as measured by Western blot assay. * p < 0.05. Cell experiments were repeated three times independently.