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. 2022 Apr 25;8:227. doi: 10.1038/s41420-022-00949-y

Fig. 6. JMJD2C accelerates the growth of uveal melanoma and increases CDDP resistance in nude mice via regulation of the MDM2/p53/IL5RA axis.

Fig. 6

A The expression of JMJD2C, MDM2, p53, and IL5RA in tumors derived from MUM-2B cells and MUM-2B/CDDP cells as measured by Western blot assay. B Representative images showing xenografted tumors in derived from MUM-2B cells and MUM-2B/CDDP cells and tumor growth curves. C The statistical plot for tumor weight of MUM-2B- and MUM-2B/CDDP-implanted nude mice. D Positive rates of Ki67 and PCNA in MUM-2B cell- and MUM-2B/CDDP cell-derived tumor tissues of nude mice as detected by immunohistochemistry. Scale bar = 50 μm. n = 8 for mice following each treatment. * p < 0.05.