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Histopathological features of the joints tissue with a 400 × magnification at five different fields (scale bar: 50 μm). RA animal shows infiltration of inflammatory cells compared to the normal group. Reduction of inflammatory cells is found in group treated with IPM and diclofenac. IPM: n-hexane-insoluble fraction of dichloromethane extracts of P. major; RA: Rheumatoid arthritis.
