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. 2022 Apr 12;10:852561. doi: 10.3389/fcell.2022.852561

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Copyright © 2022 Wang, Ye, Zhou, Guo, Xiong, Gong, Jiang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Abnormal formation of the labyrinth layer in the CreER ^T2 /SynA ^−/− placenta. (A,B) Anti-MCT1 and anti-MCT4 immunofluorescence staining of the CreER ^T2 /SynA ^fl/fl and CreER ^T2 /SynA ^−/− placentas at E17.5 d. Anti-MCT1 and anti-MCT4 are expressed in the labyrinth, which showed a reduced labyrinth area in the CreER ^T2 /SynA ^−/− placenta. (C,D) Unfused trophoblast cells gathered in the labyrinth layer, surrounding the morphologically abnormal STB-II, indicating that STB-I was disrupted. Moreover, the STB-II was reduced after Syncytin-A disruption. (E,F) AP staining of CreER ^T2 /SynA ^fl/fl and CreER ^T2 /SynA ^−/− placentas at E17.5 d. Overall figure (4×), partial figure (20×). (G,H) Transmission electron microscopy observation of endothelial cells (purple) in placental tissues at E17.5 d. (G) (6,000×), (H) (2,500×, for better insight on vascularization in CreER ^T2 /SynA ^−/− placentas). m: maternal lacuna; f: fetal vessel; I: STB-I; II: STB-II; *: lipid inclusion.