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. 2022 Apr 12;10:852561. doi: 10.3389/fcell.2022.852561

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Copyright © 2022 Wang, Ye, Zhou, Guo, Xiong, Gong, Jiang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CreER ^T2 /SynA ^−/

− placenta exhibit cell apoptosis and vascular deficiency. (A,B) TUNEL staining of placental tissues at E 17.5 d. TUNEL positive cells were observed in CreER ^T2 /SynA ^−/− placentas compared to CreER ^T2 /SynA ^fl/fl placenta. (C,D) Anti-MCT4 and CD34 immunofluorescence staining of CreER ^T2 /SynA ^fl/fl and CreER ^T2 /SynA ^−/− placentas (E17.5 d). Fetal blood vessels are displayed with STB-II fully and tightly (green arrowheads) in the CreER ^T2 /SynA ^fl/fl placenta [(C)-i, -ii], but were lost in the normal structure and scattered with only a small surface attached to STB-II (blue arrowheads) in CreER ^T2 /SynA ^−/− placenta [(D)-i, -ii]. Distribution schematics of the endothelial cells are shown in (C)-iii and (D)-iii, and suggest a disruption of placental vascularization after disruption of Syncytin-A. (E) MVD of CreER ^T2 /SynA ^−/− placenta was decreased (E17.5 d). ***: p < 0.001. (F–H) Relative mRNA expression levels of PLGF, VEGF and sFlt-1 of CreER ^T2 /SynA ^fl/fl and CreER ^T2 /SynA ^−/− placentas (E17.5 d). **: p < 0.01, ***: p < 0.001.