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. 2022 Apr 12;10:852561. doi: 10.3389/fcell.2022.852561

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Copyright © 2022 Wang, Ye, Zhou, Guo, Xiong, Gong, Jiang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Induced tube formation of HUVECs by conditioned medium from Syncytin-1-knockdown and control trophoblasts. (A) Schematic of tube formation by using HUVECs co-cultured with conditional supernatant from trophoblast cells. (B,C) Tube formation pictures were taken at 2 h after cultured with conditional medium from control and HERV-W siRNA-transfection cells. (D–I) Parameters for assessing the ability of tube formation. (J–O) Relative mRNA and protein expression levels of PLGF, VEGF and sFlt-1 in cells and cellular supernatant from control and HERV-W siRNA-transfected cells. (P,Q) Relative protein expression of sFlt-1/VEGF and sFlt-1/PLGF. **: p < 0.01, ***: p < 0.001.