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. 2022 Apr 12;10:852561. doi: 10.3389/fcell.2022.852561

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Copyright © 2022 Wang, Ye, Zhou, Guo, Xiong, Gong, Jiang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Syncytin-1 disruption suppressed angiogenesis via the PI3K/Akt/mTOR signaling pathway in trophoblast cells (A). Western blotting analysis of PI3K, P-Akt and mTOR proteins in BeWo and HTR-8/SVneo trophoblast cells after Syncytin-1 disruption, with α-Tubulin used as loading control (B, C). The expression levels of PI3K, P-Akt and mTOR were significantly decreased in HERV-W-silenced trophoblast cells compared with control group. ***: p < 0.001.