Table 2.
Intraocular Pressure (IOP) Outcomes at Each Postoperative Study Time Point in per Protocol Population (n=120)
| Month 1 | Month 3 | Month 6 | Month 12 | |
|---|---|---|---|---|
| Mean (SD) IOP, mmHg | ||||
| ALL (n=120) | 16.6 (6.6) | 15.1 (3.5) | 15.2 (4.0) | 15.6 (4.0) |
| POAG only (n=113) | 16.6 (6.8) | 15.0 (3.5) | 15.1 (3.9) | 15.4 (3.8) |
| PXF and PG only (n=7) | 18.1 (3.9) | 17.0 (2.2) | 18.0 (3.6) | 19.1 (6.9) |
| Eyes on 0 meds, n (%) | ||||
| ALL (n=120) | 87 (73) | 95 (79) | 96 (80) | 96 (80) |
| POAG only (n=113) | 82 (73) | 90 (81) | 90 (80) | 90 (80) |
| PXF and PG only (n=7) | 5 (71) | 5 (71) | 6 (86) | 6 (86) |
| Eyes with decrease in Diurnal IOP ≥20% at Month 12, n (%) | ||||
| ALL (n=120) | NA | NA | NA | 104 (87) |
| POAG only (n=113) | 100 (89) | |||
| PXF and PG only (n=7) | 4 (57) | |||
| Eyes on 0 meds with decrease in IOP ≥20%, n (%) | 67 (84) | 83 (92) | 87 (94) | 90 (92) |
| Eyes on 0 meds with decrease in IOP ≥20% and IOP ≥6 ≤ 18 mmHg, n (%) | 60 (75) | 79 (88) | 82 (88) | 85 (87) |
| Mean (SD) unmedicated IOP, mmHg* | 15.6 (5.2) | 14.5 (2.9) | 14.3 (3.1) | 14.6 (3.1)** |
| Mean (SD) decrease in unmedicated IOP from Baseline* | 7.7 (4.7) | 8.7 (3.2) | 9.0 (3.3) | 8.2 (4.1)** |
| Mean (SD) decrease in unmedicated IOP (%) from Baseline* | 34 (19) | 37 (12) | 39 (12) | 34 (16)** |
Notes: *Among eyes on no medications at each time point **Unmedicated IOP is measured as mean DIOP.
Abbreviations: mmHg, millimeters of mercury; SD, standard deviation; POAG, primary open-angle glaucoma; PXF, pseudoexfoliation; PG, pigmentary glaucoma.