Table 2.

Metabolic-associated pathways and genes in Bitter Melon Juice (BMJ)-treated high fat diet (HFD)- induced obese (DIO) mice. Changes in KEGG pathway-associated hepatic gene expression after BMJ treatment (unadjusted p-value≤0.05). Genes involved in 2 or more KEGG pathways are depicted in bold print. n = 4 per group.

Pathway	Gene	Ratio	p-value	FDR
Complement and coagulation cascades	C2	1.24	3.98E-02	5.72E-01
	C4b	1.35	3.74E-02	5.72E-01
	C4bp	1.37	3.98E-02	5.72E-01
	C5ar1	1.23	3.57E-02	5.72E-01
	C8a	1.74	2.52E-02	5.72E-01
	C8b	1.91	1.80E-02	5.72E-01
	C9	1.52	3.28E-02	5.72E-01
	Cfi	1.54	4.89E-02	5.72E-01
	F11	1.40	3.30E-02	5.72E-01
	Hc	1.65	3.43E-02	5.72E-01
	Masp1	1.32	4.77E-02	5.72E-01
	Masp2	1.26	4.72E-02	5.72E-01
Primary bile acid biosynthesis	Acot8	1.27	1.93E-02	5.72E-01
	Amacr	1.25	3.27E-02	5.72E-01
	Cyp7a1	1.95	2.47E-03	5.72E-01
	Slc27a5	1.29	4.89E-02	5.72E-01
Insulin resistance	Cpt1a	1.26	2.54E-02	5.72E-01
	Creb3l3	1.34	4.41E-03	5.72E-01
	Gys2	1.47	1.98E-02	5.72E-01
	Insr	1.42	4.47E-02	5.72E-01
	Pik3r1	1.42	4.16E-02	5.72E-01
	Ppp1r3b	1.59	1.90E-02	5.72E-01
	Ppp1r3e	1.43	2.92E-02	5.72E-01
	Slc27a1	1.31	1.55E-02	5.72E-01
	Slc27a2	1.24	4.11E-02	5.72E-01
	Slc27a5	1.30	4.89E-02	5.72E-01
	Trib3	0.83	2.77E-02	5.72E-01
Circadian rhythm	Cry1	1.53	3.57E-02	5.72E-01
	Nr1d1	0.31	3.83E-04	5.72E-01
	Per2	1.46	4.34E-03	5.72E-01
	Per3	1.43	1.77E-04	5.72E-01
	Rorc	2.76	9.39E-04	5.72E-01
PPAR signaling	Acsl1	1.55	3.12E-03	5.72E-01
	Angptl4	1.27	3.62E-02	5.72E-01
	Cpt1a	1.26	2.54E-02	5.72E-01
	Cyp4a32	2.27	2.71E-02	5.72E-01
	Cyp7a1	1.95	2.47E-03	5.72E-01
	Slc27a1	1.31	1.55E-02	5.72E-01
	Slc27a2	1.24	4.11E-02	5.72E-01
	Slc27a5	1.29	4.89E-02	5.72E-01
Cholesterol metabolism	Angptl4	1.27	3.62E-02	5.72E-01
	Cyp7a1	1.95	2.47E-03	5.72E-01
	Lcat	1.23	4.69E-02	5.72E-01
	Npc1	1.39	4.57E-02	5.72E-01
	Osbpl5	1.26	4.11E-02	5.72E-01