Table 3.
Top 30 compounds that correlate with Bitter Melon Juice (BMJ) effect in high fat diet (HFD)- induced obese (DIO) C57BL/6J mice liver transcriptome. Differentially expressed transcripts in hepatic RNA extracted from BMJ + DIO mice (unadjusted p-value≤0.05) were imported into the BaseSpace correlation engine by Illumina. Top 30 highly correlated compounds are displayed in the table. The Pharmaco Atlas genomic application tool identified compounds and treatments that correlate with gene expression data based on public genomic data sources.
| Compound | Compound Group | # of Studies | Correlation | Illumina Score |
|---|---|---|---|---|
| Okadaic Acid | Membrane Transport Modulators/Enzyme Inhibitors | 1 | negative | 100.00 |
| Ethylnitrosourea | Alkylating Agents | 1 | negative | 96.33 |
| Cefuroxime | Unclassified Mechanisms of Action | 1 | positive | 90.60 |
| Trilinolein | Unclassified Mechanisms of Action | 2 | positive | 88.67 |
| Cryptoxanthin | Unclassified Mechanisms of Action | 1 | positive | 86.44 |
| Aflatoxins | Unclassified Mechanisms of Action | 1 | negative | 84.40 |
| 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole | Unclassified Mechanisms of Action | 1 | positive | 84.35 |
| Genipin | Unclassified Mechanisms of Action | 1 | positive | 83.58 |
| Butylbenzyl phthalate | Unclassified Mechanisms of Action | 1 | positive | 81.59 |
| Thioacetamide | Unclassified Mechanisms of Action | 14 | negative | 80.13 |
| Malathion | Enzyme Inhibitors/Neurotransmitter Agents | 2 | negative | 79.46 |
| Heptachlor Epoxide | Unclassified Mechanisms of Action | 1 | negative | 78.94 |
| Senecionine | Unclassified Mechanisms of Action | 1 | negative | 76.54 |
| Methapyrilene | Neurotransmitter Agents | 12 | negative | 74.13 |
| N-nitrosomorpholine | Unclassified Mechanisms of Action | 1 | negative | 73.61 |
| Naphthalene | Unclassified Mechanisms of Action | 2 | negative | 73.29 |
| Colchicine | Mitosis Modulators | 8 | negative | 72.52 |
| Ibufenac | Unclassified Mechanisms of Action | 2 | positive | 72.31 |
| Miconazole | Enzyme Inhibitors | 8 | negative | 71.66 |
| Cyanoginosin LR | Enzyme Inhibitors | 3 | negative | 71.54 |
| Prednisone | Unclassified Mechanisms of Action | 5 | positive | 71.22 |
| Tunicamycin | Unclassified Mechanisms of Action | 8 | negative | 71.17 |
| Phenacetin | Unclassified Mechanisms of Action | 7 | positive | 70.88 |
| Fluocinolone Acetonide | Unclassified Mechanisms of Action | 6 | positive | 70.74 |
| Hexachlorobenzene | Unclassified Mechanisms of Action | 1 | negative | 70.65 |
| Betamethasone | Unclassified Mechanisms of Action | 3 | positive | 70.58 |
| Pristane | Unclassified Mechanisms of Action | 2 | negative | 70.50 |
| Fenofibrate | Unclassified Mechanisms of Action | 20 | positive | 70.06 |
| Direct black 3 | Unclassified Mechanisms of Action | 1 | positive | 69.95 |
| Dimethylnitrosamine | Unclassified Mechanisms of Action | 8 | negative | 69.77 |