Table 4.
MetS-related disease phenotypes in Bitter melon Juice (BMJ) treated high fat diet (HFD)- induced obese (DIO) C57BL/6J mice liver transcriptome. Differentially expressed transcripts in hepatic RNA extracted from BMJ + DIO mice were imported into the BaseSpace correlation engine by Illumina. Highly correlated phenotypes were selected from among the top 3 Metabolic Syndrome (MetS)-related disease groups. The Disease Atlas genomic application tool identified disease traits, conditions and experimental endpoints based on public genomic data sources that correlate with gene expression data based on public genomic data sources (unadjusted p-value ≤ 0.05).
| Phenotypes group | Phenotype | # of Studies | Correlation | Illumina Score |
|---|---|---|---|---|
| Nutritional and Metabolic Diseases | High fat diet | 52 | negative | 95.91 |
| Nutritional and Metabolic Diseases | Alpha-1-antitrypsin deficiency | 1 | negative | 92.45 |
| Nutritional and Metabolic Diseases | Deficiency state | 29 | positive | 84.07 |
| Nutritional and Metabolic Diseases | Ketogenic diet | 2 | positive | 82.47 |
| Nutritional and Metabolic Diseases | Hypophosphatasia | 2 | positive | 82.29 |
| Nutritional and Metabolic Diseases | Hypoalphalipoproteinemia | 3 | positive | 82.15 |
| Nutritional and Metabolic Diseases | Ischemic reperfusion injury | 7 | negative | 80.53 |
| Nutritional and Metabolic Diseases | Renal carnitine transport defect | 1 | positive | 79.13 |
| Nutritional and Metabolic Diseases | Argininosuccinate lyase deficiency | 2 | positive | 77.76 |
| Nutritional and Metabolic Diseases | Obesity | 12 | negative | 70.37 |
| Cancer | Liver cancer | 71 | negative | 94.08 |
| Cancer | Thyroid cancer | 14 | negative | 68.75 |
| Cancer | Lung cancer | 53 | negative | 66.49 |
| Cancer | Gastric cancer | 23 | negative | 66.24 |
| Cancer | Kidney cancer | 24 | negative | 65.47 |
| Cancer | Malignant tumor of intestine | 52 | negative | 64.35 |
| Cancer | Adrenal cancer | 5 | negative | 64.22 |
| Cancer | Brain cancer | 40 | negative | 63.49 |
| Cancer | Malignant tumor of muscle | 14 | negative | 62.82 |
| Cancer | Pancreatic cancer | 9 | positive | 42.43 |
| Heart and Vascular Diseases | Cardiomegaly | 13 | negative | 81.09 |
| Heart and Vascular Diseases | Cardiomyopathy | 24 | negative | 78.89 |
| Heart and Vascular Diseases | Dilated cardiomyopathy | 7 | negative | 75.28 |
| Heart and Vascular Diseases | Disorder of cardiac function | 15 | negative | 74.89 |
| Heart and Vascular Diseases | Shock | 7 | negative | 74.02 |
| Heart and Vascular Diseases | Endocarditis | 2 | negative | 73.05 |
| Heart and Vascular Diseases | Hypertrophic cardiomyopathy | 2 | negative | 72.66 |
| Heart and Vascular Diseases | Heart disease | 12 | negative | 72.13 |
| Heart and Vascular Diseases | Heart failure | 7 | positive | 70.76 |
| Heart and Vascular Diseases | Cardiovascular disease | 19 | negative | 58.75 |