Table 5.
Liquid chromatography-mass spectrometry (LC-MS) identified plasma lipid phase metabolites in Bitter Melon Juice (BMJ) treated high fat diet (HFD)- induced obese (DIO) C57BL/6J mice and key parameters. Metabolites significantly altered in the plasma of BMJ + DIO mice (FDR<0.05). n = 3 per group. Abbreviations: PC, phosphatidylcholine; PE, phosphatidylethanolamine; PS, phosphatidylserine; DG, diacylglycerol.
| Metabolite | Mass (Da) | Retention time (min) | Elemental composition | Log2 Fold Change | FDR |
|---|---|---|---|---|---|
| PC(22:6_20:4) | 853.56 | 5.00 | C50 H80 N O8 P | −1.15 | 2.25E-02 |
| PE(18:1) | 479.31 | 2.16 | C23 H46 N O7 P | −1.48 | 2.25E-02 |
| Fertaric acid | 308.05 | 0.41 | C14 H14 O9 | −2.66 | 2.25E-02 |
| Neurine | 85.09 | 0.42 | C5 H13 N O | −1.17 | 2.42E-02 |
| PE(18:1) isomer | 479.31 | 2.16 | C23 H46 N O7 P | −1.51 | 2.66E-02 |
| 25-azavitamin D3 | 384.35 | 4.09 | C26 H43 N O | −0.73 | 3.33E-02 |
| Canavalioside | 545.28 | 1.73 | C26 H42 O12 | −3.13 | 3.33E-02 |
| PS(17:1) | 508.28 | 1.70 | C23 H44 N O9 P | −1.87 | 3.33E-02 |
| PC(20:4_20:4) | 829.56 | 5.12 | C48 H80 N O8 P | −0.82 | 3.81E-02 |
| PE(22:6) | 524.30 | 3.40 | C27 H44 N O7 P | 2.16 | 3.81E-02 |
| DG(40:1) | 660.61 | 8.08 | C43 H82 O5 | 2.22 | 3.81E-02 |
| 13-Deoxytedanolide | 593.35 | 2.10 | C32 H50 O10 | −1.00 | 4.20E-02 |
| 2alpha-(benzyloxy)-1alpha,25-dihydroxy-19-norvitamin D3 | 487.41 | 2.74 | C33 H50 O4 | −0.72 | 4.20E-02 |