Table 4. Adverse drug reactions to first-line anti-TB drugs according to age group.
| Adverse drug reactions | Younger, < 60 yr | Older, ≥ 60 yr | Missing values | Total |
|---|---|---|---|---|
| Nausea | 1,240 (47.5) | 1,336 (51.2) | 35 (1.3) | 2,611 |
| Hepatic enzyme abnormalitya | 1,512 (59.7) | 971 (38.4) | 48 (1.9) | 2,531 |
| Rashb | 1,138 (54.5) | 889 (42.6) | 62 (3.0) | 2,089 |
| Pruritis | 744 (46.0) | 851 (52.6) | 22 (1.4) | 1,617 |
| Vomiting | 650 (41.0) | 925 (58.3) | 12 (0.8) | 1,587 |
| Urticaria | 417 (56.4) | 314 (42.4) | 9 (1.2) | 740 |
| Anorexia | 159 (23.0) | 522 (75.4) | 11 (1.6) | 692 |
| Dyspepsia | 250 (40.1) | 368 (59.1) | 5 (0.8) | 623 |
| Dizziness | 292 (49.7) | 287 (48.9) | 8 (1.4) | 587 |
| Arthralgia | 318 (57.5) | 230 (41.6) | 5 (0.9) | 553 |
| Diarrhea | 202 (42.5) | 270 (56.8) | 3 (0.6) | 475 |
| Headache | 290 (63.3) | 167 (36.5) | 1 (0.2) | 458 |
| Fever | 231 (59.5) | 150 (38.7) | 7 (1.8) | 388 |
| Hyperuricemia | 224 (65.3) | 115 (33.5) | 4 (1.2) | 343 |
| Myalgia | 134 (59.8) | 84 (37.5) | 6 (2.7) | 224 |
| Abdominal pain | 115 (54.0) | 97 (45.5) | 1 (0.5) | 213 |
| Malaise | 56 (34.8) | 105 (65.2) | 0 (0) | 161 |
| Eosinophilia | 44 (32.4) | 90 (67.6) | 0 (0) | 136 |
| Fatigue | 85 (68.0) | 40 (32.0) | 0 (0) | 125 |
| Leucopenia | 77 (74.8) | 26 (25.2) | 0 (0) | 103 |
| Dyspnea | 40 (43.0) | 53 (57.0) | 0 (0) | 93 |
| Thrombocytopenia | 13 (15.9) | 68 (83.0) | 1 (1.2) | 82 |
| Vision abnormality | 47 (60.3) | 25 (32.1) | 6 (7.7) | 78 |
| Tremor | 31 (41.3) | 44 (58.7) | 0 (0.0) | 75 |
| Cachexia | 21 (29.6) | 40 (56.3) | 10 (14.0) | 71 |
| Constipation | 15 (23.8) | 47 (74.6) | 1 (1.6) | 63 |
| Weight decrease | 16 (29.6) | 38 (70.4) | 0 (30.0) | 54 |
Data are shown as numbers (row %).
aHepatic enzyme abnormality includes hepatic enzyme increased, hepatic function abnormal, SGOT increased, SGPT increased ‘jaundice, hepatitis, gamma-GT increased, bilirubinemia, hepatocellular damage, and cholecystitis’; bRash includes ‘rash, rash maculopapular and rash erythematous’.