TABLE 6.
Hierarchical analysis of the personal and medication characteristics.
| Variables | Primary medical institutions | Non-primary medical institutions | OR (95% CI) |
|---|---|---|---|
| Serious/% | Serious/% | ||
| Personal characteristics | |||
| Age | |||
| Below 18 | 76/694 (10.95) | 242/1832 (13.21) | 0.808 (0.614–1.063) |
| 18–44 | 135/882 (15.31) | 227/1526 (14.88) | 1.034 (0.821–1.303) |
| 45–60 | 711/4353 (16.33) | 1145/7230 (15.84) | 1.037 (0.937–1.149) |
| Above 60 | 838/4899 (17.11) | 1474/9365 (15.74) | 1.105 (1.007–1.212)* |
| Gender | |||
| Male | 853/4982 (17.12) | 1559/9581 (16.27) | 1.063 (0.970–1.165) |
| Female | 928/5856 (15.85) | 1559/10,383 (15.01) | 1.066 (0.976–1.164) |
| Personal ADR past history | |||
| Yes | 16/137 (11.68) | 142/751 (18.91) | 0.567 (0.326–0.985) * |
| No | 1232/6991 (17.62) | 2177/13,970 (15.58) | 1.159 (1.073–1.251)** |
| Unknown | 536/3725 (14.39) | 802/5265 (15.23) | 0.935 (0.831–1.053) |
| Family ADR past history | |||
| Yes | 1/2 (50.00) | 5/9 (55.56) | 0.800 (0.037–17.196) |
| No | 1064/6185 (17.20) | 1843/11,886 (15.51) | 1.132 (1.042–1.230)** |
| Unknown | 719/4666 (15.41) | 1273/8091 (15.73) | 0.976 (0.883–1.078) |
| Drinking or Smoking | |||
| Yes | 258/1280 (20.15) | 256/1422 (18.00) | 1.150 (0.949–1.394) |
| No | 1526/9573 (15.94) | 2865/18,564 (15.43) | 1.039 (0.971–1.112) |
| Polypharmacy | |||
| Yes | 2/4 (50.00) | 15/71 (21.13) | 3.733 (0.485–28.744) |
| No | 1782/10,849 (16.43) | 3106/19,915 (15.60) | 1.064 (0.998–1.133) |
| Original disease | |||
| 1 | 1638/10,233 (15.71) | 2459/16,589 (14.82) | 1.095 (1.023–1.172)** |
| ≥2 | 146/620 (23.55) | 662/3397 (19.49) | 1.273 (1.038–1.561)* |
| Medication characteristics | |||
| Essential drugs | |||
| Yes | 1108/7163 (15.47) | 1286/7577 (16.97) | 0.895 (0.820–0.977)* |
| No | 676/3690 (18.32) | 1835/12,409 (14.79) | 1.292 (1.173–1.424)** |
| Intravenous drip | |||
| Yes | 1686/10,134 | 3034/19,240 | 1.066 (0.999–1.138) |
| No | 98/719 | 87/746 | 1.195 (0.878–1.628) |
| Medication season | |||
| Spring | 368/2630 | 772/5033 | 0.898 (0.785–1.027) |
| Summer | 499/3241 | 923/5967 | 0.995 (0.883–1.120) |
| Autumn | 741/3920 | 1006/6159 | 1.194 (1.075–1.326)** |
| Winter | 176/1062 | 420/2827 | 1.138 (0.939–1.380) |
Note: OR, odds ratio; CI, confidence interval; *p ˂ 0.05, **p ˂ 0.01.