Table 2.
Clinical, Functional and Laboratory Indexes Variations
| Baseline | 32 Weeks | 4 Years | 9 Years | 16 Years | p value | |
|---|---|---|---|---|---|---|
| ACT, mean ± SD | 12.6 ± 2.2 | 15.4 ± 3.1 | 17.5 ± 5 | 21.4 ± 3.1 | 21.5 ± 2.6 | 0.0002 |
| AQLQ, mean ± SD | 2.9 ± 0.5 | 4.2 ± 0.5 | 5.1 ± 0.9 | 5.8 ± 0.8 | 5.9 ± 0.6 | <0.0001 |
| Hospital admissions (n/patient/year), mean ± SD | 0.3 ± 0.5 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0.08 |
| Severe exacerbations (n/patient/year), mean ± SD | 3.6 ± 2.1 | 0.1 ± 0.4 | 0.1 ± 0.4 | 0.5 ± 1.1 | 0 ± 0 | <0.0001 |
| Mild-to-moderate exacerbations (n/patient/year), mean ± SD | 1.8 ± 1.2 | 1.1 ± 1.1 | 0.6 ± 0.7 | 0.4 ± 0.7 | 0.4 ± 0.7 | 0.054 |
| FEV1/FVC (%), mean ± SD | 61.9 ± 10.4 | 67 ± 7.9 | 72.7 ± 11.1 | 70 ± 8.2 | 69.7 ± 7.2 | 0.24 |
| FEV1 (%), mean ± SD | 54.8 ± 13.5 | 72.8 ± 21.4 | 76.6 ± 13.3 | 83.6 ± 18.8 | 83.1 ± 14.9 | 0.02 |
| Total IgE (IU/mL), mean ± SD | 386.9 ± 196.5 | 285 ± 201.7 | 959.5 ± 1018 | 614.4 ± 448.5 | 641.3 ± 383.9 | 0.14 |
Abbreviations: ACT, asthma control test; SD, standard deviation; AQLQ, asthma quality of life questionnaire; FEV1, forced expiratory volume in 1 second; FEV1/FVC, forced expiratory volume in 1 second/forced vital capacity; IgE, immunoglobulin E.