Table 1.

List of A-MAD approaches in preclinical models of the most common CNS proteinopathies.

Protein	Proteinopathy	Antibody format	Delivery platform	Model	Reference
α-synuclein*	Parkinson's disease and dementia with lewy bodies	VHH	rAAV5/ICV	Sprague–Dawley rats	Chatterjee et al. (11)
α-synuclein*		scFv	rAAV1/ICV	DAT-Cre rats	Chen et al. (12)
Tau*	Frontotemporal dementia	Full-length	rAAVrh.10/ICV	Tau P301S mice	Liu et al. (13)
Aβ*	Alzheimer's disease	scFv	rAAV1/ICV	3xTg-AD mice	Ryan et al. (14)
Aβ*		scFv	rAAV1/ICV	TgCRND8 mice	Levites et al. (15)
Aβ*		scFv	rAAV2/ICV	Tg2576 mice	Fukuchi et al. (16)
Aβ*		scFv	rAAV/ICV	3xTg-AD mice	Sudol et al. (17)
Aβ*		scFv	rAAV5/ICV	APPswe/PS1dE9 mice	Kou et al. (18)
Aβ*		Full-length	rAAV1/IM	Tg2576 mice	Shimada et al. (19)
Aβ*		scFv	rAAV1/IM	APPswe/PS1dE9 mice	Yang et al. (20)
Aβ*		scFv-IgG**	rAAV1/ICV	APP/PS1 mice	Elmer et al. (21)
Tau*		Full-length	rAAVrh.10/ICV	Tau P301S mice	Allen et al. (22)
Tau*		scFv	rAAV8/ICV	Tau P301S mice	Ising et al. (23)
Tau*		scFv	rAAV5/ICV	JNPL3 mice	Vitale et al. (24)
Tau*		scFv	rAAV1/ICV	rTg4510 mice	Goodwin et al. (25)
TDP-43*	Amyotrophic lateral sclerosis	scFv	rAAV9/IT	TDP-43A315T mice	Pozzi et al. (26)
SOD-1*		scFv	rAAV1/IT	SOD1G93A mice	Patel et al. (27)
SOD-1*		scFv	rAAV9/IV	SOD1G93A mice	Ghadge et al. (28)
PrPC	Prion disease	scFv	rAAV2/ICV	TSE mice	Wuertzer et al. (29)
Huntingtin*	Huntington's disease	scFv	rAAV1/ICV	B6.HDR6/1 mice	Snyder-Keller et al. (30)
Huntingtin*		scFv	rAAV6/ICV	R6/2_Tg mice	Amaro and Henderson (31)

^*Evidence for prion-like cell to cell transmission.

^**Engineered for Fc effector function.

ICV, Intracerebroventricular; IM, Intramuscular; IT, Intrathecal; IV, Intravenous; TDP-43, Transactive response DNA binding protein-43; SOD1, Superoxide dismutase 1.