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. 2022 Apr 12;13:869482. doi: 10.3389/fphar.2022.869482

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Copyright © 2022 Wang, Xu, Chen, Xu, Zhang and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MAGL inhibitor extensively change alternative splicing pattern of genes in intestinal tissue of rats with SAP. (A) Bar plot showing the MAGL regulated alternative splicing event (RASE) numbers by classifying them into nine type. (B) PCA base on Ratio value of the MAGL regulated alternative splicing event (RASE). The ellipse for each group is the confidence ellipse. The results showed that the confidence ellipsis of the three groups did not overlap and the samples were obviously discriminated; (C) Bar plot showing the MAGL regulated alternative splicing event (RASE) numbers in the four comparison groups. 480 ASEs were specifically upregulated in the SAP group compared with the control group, 1797 ASEs were specifically upregulated in the JZL184 group compared with the SAP group, 1,299 ASEs were specifically downregulated in the JZL184 group compared with the SAP group, and 531 ASEs were specifically downregulated in the SAP group compared with the control group; (D) Overlap analysis plots of RASE in each group. 97 ASEs were downregulated in the JZL184 group compared with the SAP group, but were upregulated in the SAP group compared with the control group; n = 3 in control group. n = 4 in SAP group and JZL184 group.